- We do bioinformatic
research to understand biotic systems as dynamic information
processing systems at many interconnected levels, e.g.,
- How does spatial pattern formation influence selection pressures at multiple time scales?
- How do complex gene regulation network evolve and work?
- We model
morphogenesis to fill up the missing link between gene regulation
and morphogenesis, e.g.,
- How do cellular amoeba aggregate to form a stalk?
- We study Evolutionary
Genomics to compare genome sequences and integrate highthrougput
data sets, e.g.,
- What rules govern the presence and absence of genes across genomes?
- How do protein interaction networks evolve?
- We do immunoinformatic
research to study the evolution of antigen processing and
presentation, e.g.,
- Which parts of the proteins of a virus are most immunogenic, and is that related to their similarity to self proteins?
- We model the
immune system to develop a more quantitative immunology and study
host-pathogen co-evolution, e.g.,
- How long do lymphocytes live, and how many target cell can one killer cell kill per day?
- Why is the MHC so polymorphic, and the lymphocyte repertoire so diverse?
Sequence logo of MHC ligands.
Ref: Kesmir, Prot. Eng. 2002.
Ref: Kesmir, Prot. Eng. 2002.
